There are times in almost every sector that forces of change come together to fundamentally disrupt the way that sector works. Former Intel Chairman Andy Grove calls this a strategic inflection point. Philanthropy is on the brink of its own strategic inflection point. Just as the internet changed the face of commerce, so it can change fundamentally the way that social change can happen. Today, organizations can wholesale social change or develop programs that almost overnight touch millions of people. These ‘wholesaling’ organizations share many common characteristics such as: (1) intent to impact the masses; (2) marginal, incremental cost to serve the next customer; (3) borderless service delivery; (4) grants plus’ business model; (5) redefining fundamental power relationships; (6) engage markets and market-driven solutions; (7) redirect ongoing flows of public or private sector funds to institutionalize desired change; and (8) use technology itself to provide innovative solutions. Philanthropy should define what ‘wholesaling activity’ is, recognize it, and create mechanisms that will support acceleration of wholesale social change.