Identifying solutions to complex problems will require us to let go of the old ways of working, in favor of more adaptive strategies. We must understand the interdependent nature of dominant trends impacting our cities, and address these challenges in more comprehensive ways. We must also recognize that no institution or sector alone can reverse the direction of these trends, and we can no longer afford to work on these challenges through par- allel efforts. And, we must take advantage of innovations in financing and harness the power of technology to accelerate and scale our work. This report is meant to serve as a high-level analysis of the trends impacting low-income city residents, and offers our thoughts on how to address these challenges more strategically.